曹治兴，博士、副研究员、硕士生导师、就职于药学院；四川省学术与技术带头人后备人选、四川省杰出青年科技人才项目获得者、四川省国际医学交流促进会青年委员。研究方向为中药药理学，主要从事中药抗肿瘤、抗炎和抗病毒相关有效成分活性筛选、合成与结构修饰、靶标探索、作用机制及相关新药研发研究，并开展基于人工智能的中医药学研究；课题组与四川大学、成都前沿医学中心和天府锦城实验室等创新医药科研平台具有良好的合作关系，可前往交流学习。已获得国家自然科学基金项目3项，四川省杰出青年科技人才项目1项、中国博士后基金面上项目1项，参与四川省科技厅创新团队项目、重大科技支撑计划项目和四川省中医药管理局项目多项。至今，以第一作者或通讯作者身份已在J Hazard Mater、Leukemia、Clin Cancer Res、Biosen Bioelectron、Pharmac Res、phytomedicine、J Nanobiotechnology、Food Chem、FASEB J、Mol Pharm、J Nat Prod、J Ethnopharm等国际知名SCI期刊发表论文四十余篇。

      联系方式：caozhixing007@163.com

在研项目

(1) 国家自然科学基金项目,姜黄与KRAS抑制剂联用协同抗肿瘤的作用与机制研究, 2024-2027, 负责人

(2) 国家自然科学基金项目,甘草通过靶向FLT3对柔红霉素治疗AML的增效减毒作用与机制研究, 2022-2025, 负责人

(3) mg老虎机游戏, 青年创新团队, QNTD2022001, 中药靶向作用研究青年创新团队, 2023-2026, 负责人

部分代表性成果

(1) Jia Li, Xin Kang, Nianjia Liu, Ao Zhang, Longxuan Li, Xuan Zhao, Yuzhi Li, Houcheng Zhou, Yun Deng, Cheng Peng*, Zhixing Cao*, Yuyu Fang*. A robust H2O2-responsive AIEgen with multiple-task performance: Achieving food analysis, visualization of dual organelles and diagnosis of liver injury. Biosen Bioelectron. 2025, 276, 117276. (通讯作者，中科院一区，IF = 10.7)

(2) Longxuan Li, Jia Li, Xin Liu, Xuan Zhao, Ao Zhang, Yun Deng, Cheng Peng, Zhixing Cao*, Wim Dehaen*, Yuyu Fang*. Shortening the early diagnostic window of Hg2+-induced liver injury with a H2O2-activated fluorescence/afterglow imaging assay. J. Hazard. Mater. 2024, 480, 136059. (通讯作者，中科院一区top期刊，IF = 12.2)

(3) Zhiqiang Yang, Xin Kang, Jia Li, Longxuan Li, Xiaoping Ye, Xiaoya Liu*, Kun Chen, Yun Deng, Cheng Peng, Bo Ren*, Zhixing Cao*, Yuyu Fang*. A novel LD-targeting cysteine-activated fluorescent probe for diagnosis of APAP-induced liver injury and its application in food analysis. Food Chem. 2024, 456, 140064. (通讯作者，中科院一区，IF = 8.5)

(4) Feishi Shan, Tingrui Zhang, Chengshuang Liao, Xue Yue, Jing Zhang, Li Yan, Yanman Liu, Zhixing Cao, Min Wang, Yahui Zhang, Leyong Wang, Zhouyu Wang, Xiaoqi Yu. Red/NIR emission carbonized polymer dots based on citric acid-benzoylurea and their application in lymph nodes imaging. Chinese Chemical Letters, 2023, 34(11): 108402. (通讯作者，中科院一区，IF =9.4)

(5) Jinfeng Shi, Yali Ren, Jiaqi Ma, Xi Luo, Jiaxin Li, Yihan Wu, Huan Gu, Chaomei Fu, Zhixing Cao^?, Jinming Zhang^?. Novel CD44-targeting and pH/redox-dual-stimuli responsive core-shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis, J Nanobiotechnology, 2021, 19(1): 188(通讯作者，中科院一区，IF = 10.6)

(6) Miao Wang, Ruoqi Zhang, Wim Dehaen, Yuyu Fang, Shan Qian, Yali Ren, Fang Cheng, Yuying Guo, Chuanjie Guo, Yuzhi Li, Yun Deng, Zhixing Cao^?, Cheng Peng^?. Specific recognition, intracellular assay and detoxification of fluorescent curcumin derivative for copper ions, J Hazard Mater, 2021, 420: 126490(通讯作者，中科院一区，IF = 12.2)

(7) Xiaominting Song, Huanan Rao, Chuanjie Guo, Bo Yang, Yali Ren, Miao Wang, Yuzhi Li, Zhixing Cao^?, Jin Pei^?. Myricetin exhibit selective anti-lymphoma activity by targeting BTK and is effective via oral administration in vivo, Phytomedicine, 2021, 93: 153802 (通讯作者，中科院一区，IF = 6.7)

(8) Chuanjie Guo, Junlin He, Xiaominting Song, Lu Tan, Miao Wang, Peidu Jiang, Yuzhi Li, Zhixing Cao^?, Cheng Peng^?. Pharmacological properties and derivatives of shikonin-A review in recent years. Pharmacol Res. 2020;149:104463(通讯作者，IF =9.3，高被引论文)

(9) Zhixing Cao, Huanan Rao, Wenya Yang, Xiaoxue Hu, Xin Kang, Daoyin Gong, Xiaominting Song, Yali Ren, Cheng Peng, Yuzhi Li*, Jin Pei*. Luteolin Mitigates Acute Lung Injury Through Immune Modulation and Antinecroptosis Effects by Targeting the BTK and FLT3 Signaling Pathways. J Agric Food Chem. 2025; 73(9): 5180-5193. (第一作者, 封面论文, 中科院一区, IF=5.7 )

(10) Zhixing Cao, Jingjing Liu, Renlin Zheng, Jiao Yang, Lei Zhong, Yong Xu, Lijiao Wang, Chunhui Zhang, Binglin Wang, Shuang Ma, Zerong Wang, Huanzhang Xie, Yuquan Wei, Shengyong Yang*, SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable potency in that of CML harboring Abl mutants. Leukemia, 2012: 26, 1892-1895 (第一作者, 中科院一区, IF=12.2 )