一、个人简介

李玉芝，博士、副教授、硕士生导师，现任职于药学院。研究方向聚焦于中药药理学，主要涉及中药抗肿瘤和免疫调控相关有效成分的活性筛选、合成与结构修饰、靶标鉴定、作用机制及相关新药研发；同时，还致力于新型生物化学信号荧光探针分析新技术与新方法的构建研究。已成功获得国家自然科学基金项目及子课题2项，四川省科技厅重大科技支撑计划项目1项，中国博士后基金面上项目1项，以及四川省中医药管理局青年科学基金1项。作为合作单位负责人，作为合作单位负责人承担四川省科技厅项目多项。至今，以第一作者或通讯作者身份已在J Agri Food Chem、Phytother Res、J Med Chem、Sensor. Actuat. B -Chem、 Eur J Med Chem、FASEB J、Anal Bioanal Chem、Mol Ecol Resour、Biomed Pharmacother、Dyes Pigments、Microchem J等国际知名SCI期刊发表论文近20余篇。

     联系方式：liyuzhi5654@163.com

二、代表性科研成果

(1) Zhixing Cao, Huanan Rao, Wenya Yang, Xiaoxue Hu, Xin Kang, Daoyin Gong, Xiaominting Song, Yali Ren, Cheng Peng, Yuzhi Li^*, Jin Pei^*. Luteolin Mitigates Acute Lung Injury Through Immune Modulation and Antinecroptosis Effects by Targeting the BTK and FLT3 Signaling Pathways. J Agric Food Chem. 2025; 73(9): 5180-5193. (通讯作者, 封面论文, 中科院一区, IF=5.7 )

(2) Yali Ren, Jieting Lei, Tingrui Zhang, Peng Lu, Dandan Cui, Bo Yang, Guiying Zhao, Fu Peng,, Zhixing Cao, Cheng Peng^*, Yuzhi Li^*. Isobavachalcone, a natural sirtuin 2 inhibitor, exhibits antitriple-negative breast cancer efficacy in vitro and in vivo, Phytother Res. 2024; 38(4): 1815-1829. (通讯作者, 中科院二区, IF=6.1)

(3) Longxuan Li, Xuan Zhao, Yin Tian, Jia Li, Zhiqiang Yang, Xin Liu, Yuzhi Li^*, Zhixing Cao, Cheng Peng, Yun Deng^*, Wim Dehaen^*, Yuyu Fang^*. A novel fluorescent probe with tailored properties for ozone: applications in on-site environmental monitoring and real-time bioimaging in Parkinson’s disease models. Sensor. Actuat. B -Chem. 2024, 418, 136248. (通讯作者，中科院一区，IF=8.0)

(4) Jia Li, Zhiqiang Yang, Wenya Yang, Xuan Zhao, Longxuan Li, Zhixing Cao, Houcheng Zhou, Renlin Zheng, Yun Deng, Cheng Peng^*, Yuzhi Li^*, Yuyu Fang^*. A novel AIE-based mitochondria-targeting fluorescent probe for monitoring of the fluctuation of endogenous hypochlorous acid in ferroptosis models. Anal. Bioanal. Chem. 2024, 416, 4873-4885. (通讯作者，中科院二区，IF=3.8)

(5) Xinyu Zhou, Duanna Zhang, Jieting Lei, Jixia Ren, Bo Yang, Zhixing Cao^*, Chuanjie Guo^*, Yuzhi Li^*. Polyphyllin I induces rapid ferroptosis in acute myeloid leukemia through simultaneous targeting PI3K/SREBP-1/SCD1 axis and triggering of lipid peroxidation. J Nat Med. 2024; 78(3): 618-632. (通讯作者)

(6) Guiying Zhao, Yali Ren, Jie Yan, Tingrui Zhang, Peng Lu , Jieting Lei, Huanan Rao, Xin Kang, Zhixing Cao, Fu Peng, Cheng Peng, Chaolong Rao^*, Yuzhi Li^*. Neoprzewaquinone A Inhibits Breast Cancer Cell Migration and Promotes Smooth Muscle Relaxation by Targeting PIM1 to Block ROCK2/STAT3 Pathway. Int J Mol Sci. 2023 Mar 13;24(6):5464.(通讯作者，中科院二区，IF=4.9)

(7) Feng Liang, Wanyun Huang, Lei Wu, Yihong Wu, Tingrui Zhang, Xiaolong He, Zhouyu Wang, Xiaoqi Yu, Yuzhi Li^*, Shan Qian^*. A NIR fluorescent probe for dual imaging of mitochondrial viscosity and FA in living cells and zebrafish. Analyst. 2023 Mar 27;148(7):1437-1441. (通讯作者，中科院二区，IF=3.8)

(8) Cui Huo, Zongyuan Luo, Xiangli Ning, Xin Kang, Qin Yan, Yuying Guo, Guobo Li, Zhouyu Wang, Yuzhi Li^*, Shan Qian^*. 4,6-Disubstituted-1H-Indazole-4-Amine derivatives with immune-chemotherapy effect and in vivo antitumor activity. Eur J Med Chem. 2022 5;241:114625. (通讯作者，中科院二区，IF=6.0)

(9) Dongbin Zheng, Tingrui Zhang, Ying Huang, Hanlin Chen, Yuzhi Li*, Zhixing Cao, Yun Deng, Yuyu Fang^*, Cheng Peng^*, Phenoxazine-conjugated-benzoeindolium as a novel mitochondria-targeted fluorescent probe for turn-on detection of sulfur dioxide and its derivatives in vivo[J]. Microchem J, 2022, 175:107192. (通讯作者，中科院二区，IF=4.9 )

(10) Xiaominting Song, Lu Tan, Miao Wang, Chaoxiang Ren, Chuanjie Guo, Bo Yang, Yali Ren, Zhixing Cao, Yuzhi Li*, Jin Pei^*. Myricetin: A review of the most recent research. Biomed Pharmacother. 2021 ;134:111017 （通讯作者，高被引论文）

(11) Xiangli Ning^#, Yuzhi Li^#, Cui Huo, Ji Deng, Cheng Gao, Kairong Zhu, Miao Wang, Yuxiang Wu, Junlin Yu, Yali Ren, Zongyuan Luo, Gen Li, Yang Chen, Zhouyu Wang, Siyao Wang, Cheng Peng Lingling Yang, Yong Wu, Shan Qian, Guobo Li. X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease. J Med Chem. 2021 24;64(12):8303-8332. (共一，中科院一区，IF=6.9)

(12) Yali Ren, Xiaominting Song, Lu Tan, Chuanjie Guo, Miao Wang, Hui Liu, Zhixing Cao, Yuzhi Li*, Cheng Peng^*. A Review of the Pharmacological Properties of Psoralen. Front Pharmacol. 2020 Sep 4;11:571535. (通讯作者，中科院二区，IF=4.4 )

(13) Zhixing Cao^#, Chuanjie Guo^#, Xiaominting Song, Junlin He, Lu Tan, Si Yu, Ruoqi Zhang, Fu Peng, Cheng Peng* and Yuzhi Li*. Erlotinib is effective against FLT3-ITD mutant AML and has the potential to overcome intratumoral heterogeneity via targeting FLT3 and Lyn. FASEB J, 2020, 34(8), 10182–10190. (通讯作者，中科院二区，IF=4.4 )

(14) Junlin He, Si Yua, Chuanjie Guo, Lu Tan, Xiaominting Song, Miao Wang, Jing Wu, Yuling Long, Daoyin Gong, Ruoqi Zhang, Zhixing Cao, Yuzhi Li*, Cheng Peng?. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189. (通讯作者，中科院二区，IF=6.9 )

(15) Lingling Yang, Yang Chen, Junlin He, Emmanuel

Mfotie Njoya, Jianjun Chen, Siyan Liu, Congqiang Xie, Wenze Huang, Fei Wang, Zhouyu Wang*, Yuzhi Li*, ShanQiana^*. 4, 6-Substituted-1H-Indazoles as Potent IDO1/TDO Dual Inhibitors[J]. Bioorganic & Medicinal Chemistry, 2019;27(6):1087-1098.

(16) Yue Zhang, Yun Deng, Ningping Ji, Jiahao Zhang, Chenmeng Fan, Tieying Ding, Zhixing Cao, Yuzhi Li^*, Yuyu Fang^*. A rationally designed flavone-based esipt fluorescent chemodosimeter for highly selective recognition towards fluoride and its application in live-cell imaging. Dyes & Pigments, 2019;166, 473-479?