杨苏瓃鑫，副研究员，硕士生导师，生物医药博士，mg老虎机游戏引进人才，本草基因组学研究院药物化学课题组组长。于四川大学获得药学硕士学位，于澳门大学获得生物医药博士学位。主要研究方向为纳米药物/基因递送系统开发，已发表SCI论文17篇，Google Scholar总引用828次；获得中国博士后特别资助C档、中国博士后科学基金面上资助等项目。以第一/共同第一作者发表SCI论文7篇，包括Advanced Materials（IF= 27.4）、Nano Today （IF= 13.2）、Acta Biomaterialia（IF= 9.4）、Journal of Controlled Release（IF= 10.5）、Theranostics（IF= 12.8）等。申请专利一项。Exploration青年编委。
?联系方式：yangsulation@qq.com

一、研究领域

高分子药物/基因递送材料

靶向胞外蛋白降解

中药活性成分与GPCR相互作用

二、代表性成果

1. Yang S#, Wu Y#, Zhong W, Chen R, Wang M, Chen M*. GSH/pH Dual Activatable Crosslinked and Fluorinated PEI for Cancer Gene Therapy through Endogenous Iron De-Hijacking and in situ ROS Amplification[J]. Advanced Materials, adma.202304098.

2. Yang S, Chen R, Hua P, Wu Y, Chen M*. Integrating Autophagy Inhibition and ROS Clearance in Biohybrid Nanoparticles for Potent Low-Temperature Photothermal Cancer Therapy [J]. Nano Today, Accepted.

3. Yang S, Chen R, Wu Y, Song X* , Peng X* , Chen M*. Fluorinated polyethyleneimine vectors with serum resistance and adjuvant effect to deliver LMP2 mRNA vaccine for nasopharyngeal carcinoma therapy [J]. Acta Biomaterialia, 2025, 192: 340-352.

4. Yang S#, Wong K#, Hua P#, He C, Yu H, Shao D, Shi Z, Chen M*. ROS-Responsive Fluorinated Polyethyleneimine Vector to Co-deliver shMTHFD2 and shGPX4 Plasmids Induces Ferroptosis and Apoptosis for Cancer Therapy[J]. Acta Biomaterialia, 2022, 140: 492-505.

5. Yang S#, Ou C#, Wang L#, Liu X, Yang J, Wang X, Wang M, Shen M, Wu Q, Gong C*. Virus-esque Nucleus-Targeting Nanoparticles Deliver Trojan Plasmid for Release of Anti-Tumor Shuttle Protein [J]. Journal of Controlled Release, 2020, 320: 253-264.

6.Yang S, Wu Q, Wei Y, Gong C*. CRISPR-Cas9 delivery by artificial virus (RRPHC)[M]//CRISPR Gene Editing. Humana Press, New York, NY, 2019: 81-91.

7. Liu X#, Yang S#, Wang L#, Wu X, Wang X, Ou C, Yang J, Song L, Zhou S, Wu Q*, Gong C*. Hierarchically Tumor-activated nanoCRISPR-Cas13a Facilitates Efficient microRNA Disruption for Multi-Pathway-Mediated Tumor Suppression[J]. Theranostics, 2023; 13(9): 2774-2786.

8. Li L#, Yang S#, Song L, Zeng Y, He T, Wang N, Yu C, Yin T, Liu L, Wei X, Wei Y, Yang L, Gong C*. An Endogenous Vaccine Based on Fluorophores and Multivalent Immunoadjuvants Regulates Tumor Micro-Environment for Synergistic Photothermal and Immunotherapy[J]. Theranostics, 2018, 8(3): 860.

9. Hua P, Liang R, Yang S, Tu Y, Chen M*. Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis. Bioactive Materials. 2024, 36: 83-95.