一、个人简介

 白兰，博士，四川省医学科学院·四川省人民医院药学部主任中药师，电子科技大学副教授，硕士研究生导师。香港大学访问学者，四川省中医药发展促进会理事，四川省中医药发展促进会制剂专业委员常务委员，四川省中医药学会理事，四川省中医药学会方剂学专业委员会委员，世界中医药联合会道地药材多维评价专业委员会会员，Chinese Herbal Medicines 青年编委。研究方向：中药、天然产物的作用机制以及转化研究，具体包括中药、天然产物抗肿瘤和抗衰老的作用机制研究，新制剂的应用研究。累计主持参与国家和省级各项课题11项，发表SCI论文40余篇，专利3项，参编书籍2项。

     Email：blci@163.com

     座机：028-87383346

二、代表性成果（可含承担项目、发表论文、论著、获奖等）

（一）承担项目

1.四川省科技厅，2024ZDZX0010，高原环境作业人员健康保障关键技术研究-高原作业人员特需能量棒研发；

2.四川省科技厅，2023NSFSC0685，基于靶点钩钓策略探索中药鸦胆子调控肝癌的物质基础和作用机制研究；

3.西南特色中药资源国家重点实验室， SKLTCM2022019，川芎及其活性成分调控衰老大鼠神经元线粒体损伤作用机制研究；

4.四川省中药管理局项目，2023MS222，基于衰老大鼠神经元线粒体探索道地药材川芎保护神经元细胞的作用机制；

5.四川省卫健委，20PJ095，短肽自主装-乳糖酸肝靶向载药纳米粒设计； 

6.四川省卫健委，18PJ548，新德里金属β-内酰胺酶-1（NDM-1）抑制剂的设计、结构优化及活性研究； 

7.院青年人才基金，2016QN08，以雷公藤甲素为先导靶向TFIIH蛋白亚基XPB的新型抗肿瘤药物分子设计与活性研究；

8.四川省科技厅  科技支撑计划子课题，2015SZ0039，中医药特色医院制剂的发掘、研发与质量提升研究-一贯煎颗粒剂的研发；

9.四川省卫计委，150211，基于计算机辅助的MEK 抑制剂的设计、合成及抗肿瘤活性研究

（二）发表论文

1.Qichuan Deng, Yu Huang, Jing Zeng, Xinyu Li, Xianyi Zheng, Li Guo, Jianyou Shi, Lan Bai^#. Recent advancements in the small-molecule drugs for hepatocellular carcinoma (HCC): Structure-activity relationships, pharmacological activities, and the clinical trials. Biomedicine & Pharmacotherapy. 179 (2024) 117343.

2.Jing Chen, Dongke Yu1, Xinyu Li, Qichuan Deng, Hao Yang, Lu Chen and Lan Bai^#. A review of Brucea javanica: metabolites, pharmacology andmclinical application. Front. Pharmacol. 14 (2024) 1317620.

3.Lan Bai^#, Ting Wang, Qichuan Deng, Wei Zheng, Xinyu Li , Hao Yang ,Rongsheng Tong*, Dongke Yu*, Jianyou Shi*. Dual properties of pharmacological activities and preparation excipient: Bletilla striata polysaccharides. International Journal of Biological Macromolecules 254 (2024) 127643.

4.Yitong Tong, Xinyu Li, Qichuan Deng, Jianyou Shi*, Yibin Feng*, Lan Bai*; Advances of the small molecule drugs regulating fibroblast-like synovial proliferation for rheumatoid arthritis. Frontiers in Pharmacology, 2023, 14.

5.Qinan Yin, Liuyun Wu, Lizhu Han, Xingyue Zheng, Rongsheng Tong, Lian Li, Lan Bai*, Yuan Bian*; Immune-related adverse events of immune checkpoint inhibitors: a review, Front Immunol, 1411679752023

6.Ruijie Liu, Li He, Maoyu Liu, Lu Chen, Jun Hou*, Jianyou Shi*, Lan Bai*; Erythrocyte membrane encapsulated gambogic acid nanoparticles as a therapeutic for hepatocellular carcinoma. Chinese Chemical Letters, 2023, 34(1)

7.Haoyuan Peng, Lei Zhong, Lin Cheng, Lu Chen, Rongsheng Tong, Jianyou Shi*, Lan Bai*；Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis. Frontiers in Pharmacology, 2023, 13.

8.Qi Liang, Maoyu Liu, Jian Li, Rongsheng Tong, Yonghe Hu*, Lan Bai*, Jianyou Shi*；NAE modulators: A potential therapy for gastric carcinoma [J]. European journal of medicinal chemistry, 2022, 231: 114156

9.Bingyao Xu#, Lan Bai#, Lu Chen, Rongsheng Tong*, Yibin Feng* and Jianyou Shi*; Terpenoid natural products exert neuroprotection via the PI3K/Akt pathway . Frontiers in pharmacology, 2022, 13: 1036506

10.Qiaoqiao Hu*, Lan Bai*, Zejiang Zhu, Zhengying Su, Peng Bai, Minghai Tang, Caixia Dou, Junfeng Yan, Rongsheng Tong, Wuyu Zhang, Lijuan Chen, Lulu Cai#；β-Elemene-loaded polymeric micelles intensify anti-carcinoma efficacy and alleviate side effects, Chinese Chemical Letters,2020, 31(3):915-918

11.Li He, Qian Su, Lan Bai*, Meifeng Li, Juanru Liu, Xiaomei Liu, Cunyan Zhang, Zhongliang Jiang, Jun He, Jianyou Shi^#, Shan Huang^#, Li Guo^#; Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species, European journal of medicinal chemistry,2020,204:112530

12.Jing Zhao, Jinqi Li, Zhongliang Jiang, Rongsheng Tong, Xingmei Duan, Lan Bai^#, Jian-You Shi^#; Chitosan, N,N,N-trimethyl chitosan (TMC) and 2-hydroxypropyltrimethyl ammonium chloride chitosan (HTCC): The potential immune adjuvants and nano carriers ,International journal of biological macromolecules, 2020,154:339-348

13.Yu Zheng*, Lan Bai*, Yanping Zhou , Rongsheng Tong , Minghui Zeng c, Xiaofang Li#, Jianyou Shi#; Polysaccharides from Chinese herbal medicine for anti-diabetes recent advances, International Journal of Biological Macromolecules, 2019,121:1240-1253

14.Lan Bai*, Xiaofang Li*, Li He, Yu Zheng, Haiying Lu, Jinqi Li, Lei Zhong, Rongsheng Tong, Zhongliang Jiang, Jianyou Shi#. Antidiabetic Potential of Flavonoids from Traditional Chinese Medicine: A Review. The American Journal of Chinese Medicine,2019,47(5):933-957

15.Ting Wanga*, Zhuyu Xua*, Yongping Lua*, Jianyou Shi, Wenbo Liu, Chengchen Zhang, Zhongliang Jiang, Baowen Qi# and Lan Bai^#, Recent Progress tort the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers, Current Topics in Medicinal Chemistry, 2019, 19(12): 1051-1058;

16.Haiying Lu*, Lan Bai*, Yanping Zhou*, Yongping Lu, Zhongliang Jiang# and Jianyou Shi#. Recent Study of Dual HDAC/PARP Inhibitor for the Treatment of Tumor. Current topics in medicinal chemistry, 2019,19(12): 1041-1050

（三）专利

1. 一种红细胞膜包裹藤黄酸的仿生纳米颗粒、制备方法及其应用(ZL 202110905801.2)

2. 一种榄香烯聚合物胶束制剂及其制备方法和应用（ZL201911227311.0）