胡川
一、 个人简介
胡川，特聘副研究员，硕士生导师。2012-2022年于四川大学华西药学院药剂学系学习并获得理学博士学位。2023年6月通过高层次人才引进至mg老虎机游戏药学院工作。在Advanced Functional Materials, Biomaterials, Acta Pharmaceutica Sinica B, Advanced Drug Delivery Reviews等期刊以第一/通讯作者发表SCI论文10余篇，H因子为24。先后获得“国家自然科学基金青年项目、国家资助博士后研究人员计划、四川省自然科学基金青年项目”等资助。
二、 研究方向
1. 微环境响应型递释系统的设计与评价
2. 脑靶向高效递释系统的设计与评价
三、 部分代表性研究成果
1. Li Fu, Ziye Su, Shuyang Wu, Yanfen Cheng, Chuan Hu*, Jinming Zhang*. Redox-responsive hyaluronic acid-celastrol prodrug micelles with glycyrrhetinic acid co-delivery for tumor combination therapy. Chinese Chem Lett. 2024. (IF=9.401)
2. Jinfeng Shi, Yehui Wang, Yihan Wu, Jingjing Li, Chaomei Fu, Yi Li, Xingliang Xie, Xiaohong Fan, Yichen Hu, Chuan Hu*, Jinming Zhang*. Tumor Microenvironment ROS/pH Cascade-Responsive Supramolecular Nanoplatform with ROS Regeneration Property for Enhanced Hepatocellular Carcinoma Therapy. ACS Appl Mater Inter, 2024, 16(6):7576-7592. IF=9.5)
3. Hu Chuan#, Wu Baoyu#, Wu Yihan, Shi Mingyi, Ma Jiaqi, Gao Huile*, Zhang Jinming*. Recent advances in nanotechnology for combating Alzheimer's disease. Mater Chem Front, 2023, 7(21): 5171-5186. (IF=7)
4. Hu Chuan#, Song Yujun#, Zhang Yiwei, He Siqin, Liu Xueying, Yang Xiaotong, Gong Tao, Huang Yuan, Gao Huile*. Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome. Acta Pharm Sin B, 2023, 13(5): 2176-2187. (IF=14.5)
5. Hu Chuan, Gao Huile*. A cleavable self-delivery nanoparticle for tumor photo-immunotherapy. Asian J Pharm Sci, 2021, 16(4): 133-135. (IF=9.273)
6. Hu Chuan, He Xueqin, Chen Yuxiu, Yang Xiaotong, Qin Lin, Lei Ting, Zhou Yang, Gong Tao, Huang Yuan, Gao Huile*. Metformin mediated PD-L1 downregulation in combination with photodynamic-immunotherapy for treatment of breast cancer. Adv Funct Mater, 2021, 31(11), 2007149. (IF=19.000)
7. Hu Chuan, Lei Ting, Wang Yazhen, Cao Jun, Yang Xiaotong, Qin Lin, Liu Rui, Zhou Yang, Tong Fan, Umeshappa Sokke Channakeshava*, Gao Huile*. Phagocyte-membrane-coated and laser-responsive nanoparticles control primary and metastatic cancer by inducing anti-tumor immunity. Biomaterials, 2020, 255, 120159. (IF=10.317)
8. Hu Chuan, Cun Xingli, Ruan Shaobo, Liu Rui, Xiao Wei, Yang Xiaotong, Yang Yuanyuan, Yang Chuanyao, Gao Huile*. Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy. Biomaterials, 2018, 168: 64-75. (IF=10.273)
9. Hu Chuan, Yang Xiaotong, Liu Rui, Ruan Shaobo, Zhou Yang, Xiao Wei, Yu Wenqi, Yang Chuanyao, Gao Huile*. Coadministration of iRGD with multistage responsive nanoparticles enhanced tumor targeting and penetration abilities for breast cancer therapy. ACS Appl Mater Inter, 2018, 10(26):22571-22579. (IF=8.456)
10. Yu Wenqi#, Hu Chuan#, Gao Huile*. Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages. Adv Drug Deliv Rev, 2021, 178: 113909. (IF= 17.873)